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Accession IconGSE25866

Expression data from DU145 cells treated with ST3-Hel2A-2 STAT3 N-domain inhibitor coupled to analysis of genome-wide STAT3 binding sites

Organism Icon Homo sapiens
Sample Icon 6 Downloadable Samples
Technology Badge Icon Affymetrix Human Genome U133A 2.0 Array (hgu133a2)

Submitter Supplied Information

Description
Activation of Signal Transducer and Activator of Transcription 3 (STAT3) is common in prostate cancers. STAT3 may induce cell proliferation and resistance to apoptosis, as well as promote tumor angiogenesis, invasion, and migration by activating gene expression. Many STAT3-dependent transcriptional responses are mediated through protein-protein interactions that involve the amino-terminal domain (N-domain).
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Total Samples
6
Submitter’s Institution

Samples

Show of 6 Total Samples
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Title
Cell line
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Additional Metadata
DU145 control-3
du145 prostate cancer cell line
DU145 ST3-Hel2A-2-1
du145 prostate cancer cell line
DU145 ST3-Hel2A-2-3
du145 prostate cancer cell line
DU145 control-2
du145 prostate cancer cell line
DU145 control-1
du145 prostate cancer cell line
DU145 ST3-Hel2A-2-2
du145 prostate cancer cell line
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