GSE5324TTP mRNA targets identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts
Mus musculus
48 Downloadable Samples
Affymetrix Mouse Genome 430 2.0 Array (mouse4302)Submitter Supplied Information
Description
Tristetraprolin (TTP) is a tandem CCCH zinc finger protein that was identified through its rapid induction by mitogens in fibroblasts. Studies of TTP-deficient mice, and cells derived from them, showed that TTP could bind to certain AU-rich elements in mRNAs, leading to increases in the rates of mRNA deadenylation and destruction. Known physiological target
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TTP_WT_90ActD_BioRep2
fibroblast ttp wt cell line prepared from littermate e14.5 mouse embryos, derived from parental ttp +/- male and ttp +/- female strain 129/b6; embryo age: e14.5, tissue: whole embryo excluding head and organs
TTP_WT_60ActD_BioRep1
fibroblast ttp wt cell line prepared from littermate e14.5 mouse embryos, derived from parental ttp +/- male and ttp +/- female strain 129/b6; embryo age: e14.5, tissue: whole embryo excluding head and organs
TTP_WT_120ActD_BioRep1
fibroblast ttp wt cell line prepared from littermate e14.5 mouse embryos, derived from parental ttp +/- male and ttp +/- female strain 129/b6; embryo age: e14.5, tissue: whole embryo excluding head and organs
TTP_KO_60ActD_BioRep1
fibroblast ttp ko cell line prepared from littermate e14.5 mouse embryos, derived from parental ttp +/- male and ttp +/- female strain 129/b6; embryo age: e14.5, tissue: whole embryo excluding head and organs
TTP_KO_0ActD_BioRep2
fibroblast ttp ko cell line prepared from littermate e14.5 mouse embryos, derived from parental ttp +/- male and ttp +/- female strain 129/b6; embryo age: e14.5, tissue: whole embryo excluding head and organs
TTP_WT_30ActD_BioRep5
fibroblast ttp wt cell line prepared from littermate e14.5 mouse embryos, derived from parental ttp +/- male and ttp +/- female strain 129/b6; embryo age: e14.5, tissue: whole embryo excluding head and organs
TTP_WT_60ActD_BioRep5
fibroblast ttp wt cell line prepared from littermate e14.5 mouse embryos, derived from parental ttp +/- male and ttp +/- female strain 129/b6; embryo age: e14.5, tissue: whole embryo excluding head and organs
TTP_WT_30ActD_BioRep1
fibroblast ttp wt cell line prepared from littermate e14.5 mouse embryos, derived from parental ttp +/- male and ttp +/- female strain 129/b6; embryo age: e14.5, tissue: whole embryo excluding head and organs
TTP_WT_90ActD_BioRep4
fibroblast ttp wt cell line prepared from littermate e14.5 mouse embryos, derived from parental ttp +/- male and ttp +/- female strain 129/b6; embryo age: e14.5, tissue: whole embryo excluding head and organs
TTP_KO_0ActD_BioRep4
fibroblast ttp ko cell line prepared from littermate e14.5 mouse embryos, derived from parental ttp +/- male and ttp +/- female strain 129/b6; embryo age: e14.5, tissue: whole embryo excluding head and organs
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