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Accession IconGSE62198

Expression data of MLL-AF9-transformed murine leukemia progenitor cells, following treatment with UNC1999, a dual Ezh1 and Ezh2 inhibitor, or knockdown of EED

Organism Icon Mus musculus
Sample Icon 6 Downloadable Samples
Technology Badge Icon Affymetrix Mouse Gene 2.1 ST Array (mogene21st)

Submitter Supplied Information

Description
Ezh2 and EZH1 are histone H3 lysine 27 specific methyltransferase. Their hyperactive mutations and overexpression were found in cancer including various hematological malignancies. UNC1999 is a highly selective inhibitor for both enzymes. It suppresses H3K27 tri- and di-methylation globally and inhibits growth of MLL-rearranged acute leukemia cell lines. UNC2400, a di-methylated derivative of UNC1999, is employed an inactive analog compound for assessment of off-target effects. EED knockdown was used to demonstrate gene targets of PRC2.
PubMed ID
Total Samples
22
Submitter’s Institution

Samples

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Title
Specimen part
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Processing Information
Additional Metadata
MLL-AF9_shEED_2
transformed murine leukemia progenitor cell line
mll-af9-puro
MLL-AF9_shEED_1
transformed murine leukemia progenitor cell line
mll-af9-puro
MLL-AF9_shRen_1
transformed murine leukemia progenitor cell line
mll-af9-puro
MLL-AF9_shEED_3
transformed murine leukemia progenitor cell line
mll-af9-puro
MLL-AF9_shRen_2
transformed murine leukemia progenitor cell line
mll-af9-puro
MLL-AF9_shRen_3
transformed murine leukemia progenitor cell line
mll-af9-puro
Sample not processed
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MLL-AF9-puro_3M_UNC2400_D5_1
transformed murine leukemia progenitor cell line
mll-af9-puro
NA
Sample not processed
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MLL-AF9-puro_3M_UNC1999_D5_3
transformed murine leukemia progenitor cell line
mll-af9-puro
NA
Sample not processed
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MLL-AF9-GFP_3M_UNC1999_D5_5
transformed murine leukemia progenitor cell line
mll-af9-ires-gfp
NA
Sample not processed
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MLL-AF9-puro_3M_UNC2400_D5_3
transformed murine leukemia progenitor cell line
mll-af9-puro
NA
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