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Accession IconGSE77379

The Marrow Niche Controls The Cancer Stem Cell Phenotype Of Disseminated Prostate Cancer

Organism Icon Homo sapiens
Sample Icon 16 Downloadable Samples
Technology Badge Icon Affymetrix Human Gene 2.1 ST Array (hugene21st)

Submitter Supplied Information

Description
Dissemination of cancer stem cells (CSCs) serves as the basis of metastasis. Recently, we demonstrated that circulating prostate cancer (PCa) targets the hematopoietic stem cell (HSCs) niche in marrow during dissemination. Once in the niche, disseminated tumor cells (DTCs) may remain dormant for extended periods. As the major function of the HSC niche is to maintain stem cell functions, we hypothesized that the niche regulates CSC activities of DTCs. We show that DTCs recovered from marrow were significantly enriched for a CSC phenotype. Critically, the conversion of DTCs to CSCs is regulated by niche. The data demonstrate that the niche plays a significant role in maintaining tumor-initiating PCa in marrow and suggests a functional relationship between CSCs and dormancy. Understanding how the marrow niche regulates the conversion of DTCs to CSCs is critical for the development of therapeutics specifically targeting skeletal bone metastasis and dormancy.
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Total Samples
16
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Samples

Show of 16 Total Samples
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Shiozawa_005_011
pc3
Shiozawa_016_038
c4-2b
Shiozawa_010_032
c4-2b
Shiozawa_013_035
pc3
Shiozawa_001_001
c4-2b
Shiozawa_003_009
pc3
Shiozawa_015_037
c4-2b
Shiozawa_002_002
c4-2b
Shiozawa_012_034
pc3
Shiozawa_008_030
pc3
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