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Accession IconSRP156888

Endogenous RAC1 P29S in mouse melanoma

Organism Icon Mus musculus
Sample Icon 12 Downloadable Samples
Technology Badge IconIllumina HiSeq 4000

Submitter Supplied Information

Description
We studied the effects of endogenous expression of the melanoma oncogene RAC1 P29S in BRAF V600E;PTEN hemizygous mouse melanomas. Overall design: Transgenic mice with a conditional knock-in of the P29S mutation in the endogenous Rac1 locus were generated and crossed onto C57BL/6J, Tyr-CreER;BrafCA/wt;Ptenfl/wt mice. Melanomas were induced by topical 4OH-tamoxifen. We compared the gene expression profile in whole tumour lysates from Tyr-CreER+/-;Ptenfl/wt;BrafCA/wt;Rac1LSL-P29S/wt mice versus Tyr-CreER+/-;Ptenfl/wt;BrafCA/wt;Rac1wt/wt mice (n = 6 tumours from 5-6 animals per group).
PubMed ID
Total Samples
12
Submitter’s Institution
No associated institution

Samples

Show of 12 Total Samples
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Accession Code
Title
Cell line
Subject
Processing Information
Additional Metadata
tum3-wt
c57bl/6j
whole tumour lysate
NA
tum12-mut
c57bl/6j
whole tumour lysate
NA
tum5-wt
c57bl/6j
whole tumour lysate
NA
tum6-wt
c57bl/6j
whole tumour lysate
NA
tum7-mut
c57bl/6j
whole tumour lysate
NA
tum1-wt
c57bl/6j
whole tumour lysate
NA
tum2-wt
c57bl/6j
whole tumour lysate
NA
tum4-wt
c57bl/6j
whole tumour lysate
NA
tum8-mut
c57bl/6j
whole tumour lysate
NA
tum9-mut
c57bl/6j
whole tumour lysate
NA
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