github link
Accession IconSRP173935

Expansion of bacteriophages during disease worsens intestinal inflammation and colitis

Organism Icon Mus musculus
Sample Icon 9 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

Submitter Supplied Information

Description
Purified phage was used to prevent tumor growth in a mouse model of bacteria aggravated-colorectal cancer. Composite E. coli phage or vehicle control was added to the drinking water of specific pathogen free (SPF) APCmin mice and animals were colonized with E.coli NC101. APCmin mice displayed no overall difference in the number of tumors that formed within the small intestine, however colonization with E. coli NC101 accelerated the growth of tumors resulting in a significant increase in large tumor formation. Importantly, bacteriophage treatment of AIEC colonized APCmin animals significantly reduced E. coli colonization. Overall design: 4 week old APCmin heterozygous mice were given a cocktail of 3 E. coli phage in drinking water for 4 weeks, then challenged with E. coli NC101 via oral gavage biweekly for 2 weeks. Mice were then maintained on drinking water containing phage mixture for 2 months.
PubMed ID
Total Samples
9
Submitter’s Institution
No associated institution

Samples

Show of 9 Total Samples
Filter
Add/Remove
Accession Code
Title
Specimen part
Cell line
Treatment
Subject
Processing Information
Additional Metadata
Control_3
ileum
c57bl/6
control
ileum
NA
PhageCocktailTreatment_2
ileum
c57bl/6
phagecocktailtreatment
ileum
NA
PhageCocktailTreatment_3
ileum
c57bl/6
phagecocktailtreatment
ileum
NA
PhageCocktailTreatment_4
ileum
c57bl/6
phagecocktailtreatment
ileum
NA
PhageCocktailTreatment_5
ileum
c57bl/6
phagecocktailtreatment
ileum
NA
PhageCocktailTreatment_6
ileum
c57bl/6
phagecocktailtreatment
ileum
NA
Control_2
ileum
c57bl/6
control
ileum
NA
Control_1
ileum
c57bl/6
control
ileum
NA
Control_4
ileum
c57bl/6
control
ileum
NA
Loading...