publication_authors:Advani R Results

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Microarray (211)

Platform

Affymetrix Human Genome U133A Array (hgu133a) (141)

Affymetrix Human Gene 1.0 ST Array (hugene10st) (58)

University at Buffalo Illumina MouseWG-6 v2.0 expression beadchip (Gene version) (12)

Includes Publication

GSE60038

Genome-wide analysis of high glucose and DZNep (EZH2 inhibitor) induced gene expression by mouse podocytes

Mus musculus
12 Downloadable Samples
Illumina MouseWG-6 v2.0 expression beadchip

Description

Analysis of DZNep-induced gene expression changes in cultured podocytes. The hypothesis tested in the present study was that DZnep ultimately augments Txnip expression, increasing oxidative stress in podocytes. These results provide important information on the response of podocytes to histone methyltransferase inhibition and a possible mechanism for DZNep action in podocytes.

Publication Title

The Histone Methyltransferase Enzyme Enhancer of Zeste Homolog 2 Protects against Podocyte Oxidative Stress and Renal Injury in Diabetes.

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GSE32710

Effects of E. coli Shiga toxin on the gene expression profile of human microvascular endothelial cells

Homo sapiens
141 Downloadable Samples
Affymetrix Human Genome U133A Array (hgu133a)

Description

Changes in endothelial phenotype induced by E. coli-derived Shiga toxins (Stx) are believed to play a critical role in the pathogenesis of hemolytic uremic syndrome. Stx inactivate host ribosomes, but also alter gene expression at concentrations that minimally affect global protein synthesis. The effect of Stx on the gene expression profile of human microvascular endothelial cells was examined using the Affymetrix HG-U133A platform. Data were processed using 13 different methods and revealed 369 unique differentially expressed genes, 318 of which were up-regulated and 51 of which were down-regulated. These studies implicated activation of the CXCR4/CXCR7/SDF-1 chemokine pathway in Stx-mediated pathogenesis.