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accession-icon GSE70881
Expression analysis of draculin (drl) expressing cells in embryonic zebrafish
  • organism-icon Danio rerio
  • sample-icon 5 Downloadable Samples
  • Technology Badge Icon Zebrafish Gene 1.0 ST Array (zebgene10st)

Description

drl expression initiates during gastrulation and condenses as a band of cells at the prospective lateral embryo margin. In late epiboly, drl:EGFP is detectable as a band of scattered EGFP-fluorescent cells; after gastrulation, drl:EGFP-positive cells coalesce at the embryo margin that then in somitogenesis break down into the anterior and posterior lateral plate with subsequent cell migrations that form the posterior vascular/hematopoietic stripes and the anterior cardiovascular and myeloid precursors.

Publication Title

Chamber identity programs drive early functional partitioning of the heart.

Sample Metadata Fields

Age, Specimen part

View Samples
accession-icon GSE69775
Early gene expression of regenerating zebrafish hearts following water or atropine treatment
  • organism-icon Danio rerio
  • sample-icon 2 Downloadable Samples
  • Technology Badge Icon Affymetrix Zebrafish Genome Array (zebrafish)

Description

We report global RNA expression profiles from whole zebrafish hearts 24 hours after ventricle amputation. Zebrafish were exposed to atropine or water following surgery.

Publication Title

Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration.

Sample Metadata Fields

Specimen part, Treatment

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accession-icon GSE33373
Gene expression in Citrus sinensis fruit tissues harvested from huanglongbing-infected trees: comparison with girdled fruit
  • organism-icon Citrus sinensis
  • sample-icon 65 Downloadable Samples
  • Technology Badge Icon Affymetrix Citrus Genome Array (citrus)

Description

In this data set, we reported for the first time that huanglongbing disease (HLB) induces major changes in the expression of global genes in flavedo, vascular and juice vesicle tissues of citrus fruit.

Publication Title

Gene expression in Citrus sinensis fruit tissues harvested from huanglongbing-infected trees: comparison with girdled fruit.

Sample Metadata Fields

Specimen part

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accession-icon GSE6299
Gene expression and cell cycle arrest in a rat keratinocyte cell line exposed to 56 Fe Ions
  • organism-icon Rattus norvegicus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Rat Genome 230 2.0 Array (rat2302)

Description

The purpose of the present work was to examine gene expression patterns in a rat keratinocyte line exposed to a 56Fe ion beam

Publication Title

Gene expression and cell cycle arrest in a rat keratinocyte line exposed to 56Fe ions.

Sample Metadata Fields

No sample metadata fields

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accession-icon SRP150747
Identification of cell type specfici markers for type I and type II Hair cells in the mouse utricle using single cell RNAseq
  • organism-icon Mus musculus
  • sample-icon 112 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 1500, Illumina HiSeq 1000

Description

Single cell RNAseq analysis of hair cells isolated from the mouse utricle at three postnatal time points Overall design: Utricular hair cells were isolated at P12 (49 cells) and P100 (23 cells) and then combined with a previously published single cell data set (samples from GSE71982) containing 35 utricular hair cells isolated at P1 (Burns et al., 2015) The previously published single cell P1 samples have been re-normalized. These samples are included in this series and all processed data are available in the file ute_normalized_data.txt, available at the foot of this record.

Publication Title

Characterization of spatial and temporal development of Type I and Type II hair cells in the mouse utricle using new cell-type-specific markers.

Sample Metadata Fields

Specimen part, Subject

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accession-icon SRP043999
RNA seq analysis of day of pregnancy 14 ovine conceptuses
  • organism-icon Ovis aries
  • sample-icon 4 Downloadable Samples
  • Technology Badge IconIon Torrent Proton

Description

RNA seq analysis was conducted to determine gene expression in the day 14 ovine conceptus. This was used in conjunction with the day 14 PPARG ChIP-seq analysis to identify genes bound by PPARG which were also expressed or not expressed in the day 14 conceptus. Understanding changes in gene expression during early pregnancy is critical to improving fertility and reproductive efficiency in ruminants. Overall design: RNA seq analysis of 4 conceptuses from 4 individual Day 14 pregnant columbia/rambouillet crossbred ewes

Publication Title

Biological Roles of Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1), HSD11B2, and Glucocorticoid Receptor (NR3C1) in Sheep Conceptus Elongation.

Sample Metadata Fields

Subject

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accession-icon SRP090001
Roadmap to implantation- RNA seq of ovine LE, GE and conceptus during early pregnancy
  • organism-icon Ovis aries
  • sample-icon 52 Downloadable Samples
  • Technology Badge IconIon Torrent Proton, Illumina HiSeq 2500

Description

RNA seq analysis of laser capture microdissected luminal and glandular epithelium from ewes on day of pregnancy 10, 12, 14, 16 and 20. As well as RNA seq of whole conceptuses, and trophectoderm tissue from day 12, 14, 16 and 20 of pregnancy. Determination of gene expression changes in the uterine epithelium and conceptus during early pregnancy helps to improve our understanding of early pregnancy events and provides a basis of new strategies to improve fertility and reproductive efficiency in ruminants. Overall design: RNA seq analysis of 4 samples of each tissue type (luminal epithelium (LE), glandular epithelium (GE) and conceptus) for 4 animals. Pre-sequencing amplification of LE, GE and day 12 conceptus samples.

Publication Title

Analysis of the Uterine Epithelial and Conceptus Transcriptome and Luminal Fluid Proteome During the Peri-Implantation Period of Pregnancy in Sheep.

Sample Metadata Fields

Specimen part, Subject

View Samples
accession-icon GSE33003
Response of Sweet Orange (Citrus sinensis) to Candidatus Liberibacter asiaticus Infection
  • organism-icon Citrus sinensis
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Citrus Genome Array (citrus)

Description

Citrus greening or huanglongbing (HLB) is a devastating disease of citrus. HLB is associated with the phloem-limited fastidious prokaryotic alpha-proteobacterium Candidatus Liberibacter spp. In this report, we used sweet orange (Citrus sinensis) leaf tissue infected with 'Ca. Liberibacter asiaticus' and compared this with healthy controls.

Publication Title

Response of sweet orange (Citrus sinensis) to 'Candidatus Liberibacter asiaticus' infection: microscopy and microarray analyses.

Sample Metadata Fields

Specimen part

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accession-icon GSE19332
Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)
  • organism-icon Homo sapiens
  • sample-icon 9 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Gene expression profiling has been performed on motor cortex and spinal cord homogenates and of sporadic ALS cases and controls, to identify genes and pathways differentially expressed in ALS. More recent studies have combined the use of laser capture microdissection (LCM) with gene expression profiling to isolate the motor neurons from the surrounding cells, such as microglia and astrocytes, in order to determine those genes differentially expressed in the vulnerable cell population i.e. motor neuron.

Publication Title

Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).

Sample Metadata Fields

Specimen part, Disease

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accession-icon GSE55968
Transcriptome of Irradiated Microglia
  • organism-icon Mus musculus
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

Whole brain irradiation remains important in the management of brain tumors. Although necessary for improving survival outcomes, cranial irradiation also results in cognitive decline in long-term survivors. A chronic inflammatory state characterized by microglial activation has been implicated in radiation-induced brain injury, and here we present a comprehensive transcriptional profile of irradiated microglia.

Publication Title

Aging-like changes in the transcriptome of irradiated microglia.

Sample Metadata Fields

Age, Specimen part

View Samples
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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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