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accession-icon GSE31592
Expression data from EMRSA-15 treated with and without manuka honey
  • organism-icon Staphylococcus aureus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix S. aureus Genome Array (saureus)

Description

Manuka honey has been shown to inhibit growth in EMRSA-15 by inhibiting cell division, the mode of actin is currently unclear.

Publication Title

Synergy between oxacillin and manuka honey sensitizes methicillin-resistant Staphylococcus aureus to oxacillin.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE35976
Genome wide array analysis of endosseous implant adherent cellular phenotypes
  • organism-icon Rattus norvegicus
  • sample-icon 16 Downloadable Samples
  • Technology Badge Icon Affymetrix Rat Gene 1.1 ST Array (ragene11st)

Description

Objective: to identify the early molecular processes involved in osseointegration associated with a micro roughened and nanosurface featured implants.

Publication Title

Comparative molecular assessment of early osseointegration in implant-adherent cells.

Sample Metadata Fields

Sex, Specimen part

View Samples
accession-icon GSE33639
Global expression analysis identified a preferentially NGF-induced transcriptional program regulated by sustained MEK/ERK and AP-1 activation during PC12 differentiation.
  • organism-icon Rattus norvegicus
  • sample-icon 15 Downloadable Samples
  • Technology Badge Icon Affymetrix Rat Gene 1.0 ST Array (ragene10st)

Description

Neuronal differentiation of PC12 cells in response to NGF is a prototypical model in which signal duration determines a biological response. Sustained ERK activity induced by NGF, as compared to transient activity induced by EGF, is critical to the differentiation of these cells. To characterize the transcriptional program activated preferentially by NGF, we compared global gene expression profiles between cells treated with NGF and EGF for 2-4 hrs, when sustained ERK signaling in response to NGF is most distinct from the transient signal elicited by EGF. This analysis identified 69 genes that were preferentially upregulated in response to NGF.

Publication Title

Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation.

Sample Metadata Fields

Specimen part, Cell line, Time

View Samples
accession-icon GSE51837
Effects of exercise on gene and miRNA expression level in human monocytes
  • organism-icon Homo sapiens
  • sample-icon 24 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Impact of brief exercise on circulating monocyte gene and microRNA expression: implications for atherosclerotic vascular disease.

Sample Metadata Fields

Sex, Specimen part, Time

View Samples
accession-icon GSE41915
Impact of brief exercise on peripheral blood NK cell gene and microRNA expression in young adults
  • organism-icon Homo sapiens
  • sample-icon 24 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Impact of brief exercise on peripheral blood NK cell gene and microRNA expression in young adults.

Sample Metadata Fields

Sex, Specimen part

View Samples
accession-icon GSE11761
Brief bout of exercise alters gene expression in peripheral blood mononuclear cells of early- and late-pubertal males
  • organism-icon Homo sapiens
  • sample-icon 39 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

We compared PBMC genomic response to exercise in both early (EB) and late-pubertal boys (LB)

Publication Title

Brief bout of exercise alters gene expression in peripheral blood mononuclear cells of early- and late-pubertal males.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE14642
A Brief Bout of Exercise Alters Gene Expression and Distinct Gene Pathways in PBMC of Early- and Late-Pubertal Females
  • organism-icon Homo sapiens
  • sample-icon 39 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

We compared PBMC genomic response to exercise in both early (EG) and late-pubertal girls (LG)

Publication Title

A brief bout of exercise alters gene expression and distinct gene pathways in peripheral blood mononuclear cells of early- and late-pubertal females.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE46371
Expression data from zebrafish (Danio rerio) embryos exposed to methyl tert-butyl ether
  • organism-icon Danio rerio
  • sample-icon 36 Downloadable Samples
  • Technology Badge Icon Affymetrix Zebrafish Genome Array (zebrafish)

Description

Methyl tert-butyl ether (MTBE) has been shown to target developing vasculature in piscine and mammalian model systems. In the zebrafish, MTBE induces vascular lesions throughout development. These lesions result from exposure to MTBE at an early stage in development (6-somites to Prim-5 stages). During this time period, transcript levels of vegfa, vegfc, and vegfr1 were significantly decreased in embryos exposed to 5 mM MTBE.

Publication Title

Manipulation of the HIF-Vegf pathway rescues methyl tert-butyl ether (MTBE)-induced vascular lesions.

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE41914
Effects of exercise on gene expression level in human NK Cells
  • organism-icon Homo sapiens
  • sample-icon 24 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

We tested the hypothesis on the mechanisms responsible for the early control of NK cell function by identifying a discrete set of genes in circulating NK cells that were altered by exercise.

Publication Title

Impact of brief exercise on peripheral blood NK cell gene and microRNA expression in young adults.

Sample Metadata Fields

Sex, Specimen part

View Samples
accession-icon GSE51835
Effects of exercise on gene expression level in human monocytes
  • organism-icon Homo sapiens
  • sample-icon 24 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

We tested the hypothesis on the mechanisms responsible for the early control of monocytes function by identifying a discrete set of genes in circulating monocytes that were altered by exercise.

Publication Title

Impact of brief exercise on circulating monocyte gene and microRNA expression: implications for atherosclerotic vascular disease.

Sample Metadata Fields

Sex, Specimen part, Time

View Samples
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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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