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accession-icon GSE11467
Crosstalk between Estrogen and TNFalpha in MCF-7 Breast Cancer Cells
  • organism-icon Homo sapiens
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a)

Description

Study was carried out to examine how E2 and TNFa together influence gene expression in breast cancer cells compared to either factor alone.

Publication Title

Positive cross-talk between estrogen receptor and NF-kappaB in breast cancer.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE33232
Cancer Outlier Gene Profile Sets Elucidate Pathways and Patient-Specific Targets in Head and Neck Squamous Cell Carcinoma
  • organism-icon Homo sapiens
  • sample-icon 126 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Exon 1.0 ST Array [transcript (gene) version (huex10st)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Toward Signaling-Driven Biomarkers Immune to Normal Tissue Contamination.

Sample Metadata Fields

Disease, Disease stage

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accession-icon GSE115577
Tumor & Tumor-Adj Gene Expression in the Nurses' Health Study Cohorts
  • organism-icon Homo sapiens
  • sample-icon 434 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Transcriptome Array 2.0 (hta20)

Description

Gene expression data from the Nurses' Health Study

Publication Title

PAM50 Molecular Intrinsic Subtypes in the Nurses' Health Study Cohorts.

Sample Metadata Fields

Disease stage, Treatment

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accession-icon GSE61989
Expression data from HUVEC with YAP siRNA knockdown
  • organism-icon Homo sapiens
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 1.0 ST Array (hugene10st)

Description

YAP knockdown in HUVEC elicits proliferation and cell cycle preogression defects. YAP deficient cells caused arrest in G1 and defects in S-phase entry. The microarray analysis was conducted to identify potential YAP targets that are involved in HUVEC cell cycle regulation

Publication Title

YAP regulates S-phase entry in endothelial cells.

Sample Metadata Fields

Specimen part, Treatment

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accession-icon SRP198408
RNA sequencing in human GBM stem cells with Myc knockdown and PARP inhibitor treatment
  • organism-icon Homo sapiens
  • sample-icon 16 Downloadable Samples
  • Technology Badge IconNextSeq 500

Description

This experiment is to examine the effect of PARP inhibitor and Myc shRNA knockdown on transcriptome profiles in MYC-amplified human GBM stem cells MGG4. Overall design: There are totally 4 samples. GBM cell MGG4 expressing scramble shRNA or shRNA targeting Myc were grown in doxycycline (Dox, 1 mg/ml) for 6 days, treated with olaparib (Ola, 10 microM) or DMSO for 24h, and harvested for RNA extraction, followed by RNA sequencing

Publication Title

Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.

Sample Metadata Fields

Cell line, Treatment, Subject

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accession-icon SRP070822
Single cell transcriptomic profiling of mouse pancreatic progenitors
  • organism-icon Mus musculus
  • sample-icon 162 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

We report the transcriptome of single pancreatic cells at embryonic day e13.5 Overall design: Single cells mRNA of wild-type mouse pancreata at embryonic day 13.5

Publication Title

Single cell transcriptomic profiling of mouse pancreatic progenitors.

Sample Metadata Fields

Specimen part, Cell line, Subject

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accession-icon SRP102483
Effects of arsenic and Pseudomonas aeruginosa infection on gene expression in human airway epithelial cells
  • organism-icon Homo sapiens
  • sample-icon 43 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

Purpose: To determine effects of arsenic on gene expression in polarized primary human bronchial epithelial (HBE) cells and impact on transcriptional response to Pseudomonas aeruginosa infection Methods: mRNA profiles of HBE cells from 6 donors exposed to 0, 5, 10 or 50 ug/L total arsenic +/- Pseudomonas aeruginosa (48 samples) were generated using Illumina sequencing, aligned in CLC Genomics workbench and analyzed for DE in EdgeR Findings: 20-30 million reads were mapped per sample and transcripts were identifed that were significantly differentially expressed in response to arsenic and Pseudomonas aeruginosa Overall design: Gene expression profiles of HBE cells from 6 donors exposed to three concentrations of arsenic +/- Pseudomonas were generated using mRNA sequencing

Publication Title

Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells.

Sample Metadata Fields

Sex, Specimen part, Subject

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accession-icon GSE28289
REST ChIP-chip and knockdown expression profiling
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
  • Technology Badge IconIllumina MouseRef-8 v2.0 expression beadchip

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Coassembly of REST and its cofactors at sites of gene repression in embryonic stem cells.

Sample Metadata Fields

Cell line, Treatment

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accession-icon GSE28141
Genome-wide analysis of REST knockdown responsive gene expression in mouse ES cells
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
  • Technology Badge IconIllumina MouseRef-8 v2.0 expression beadchip

Description

Analysis of gene expression profiling upon REST shRNA knockdown in mouse ES cells for 72 hours,

Publication Title

Coassembly of REST and its cofactors at sites of gene repression in embryonic stem cells.

Sample Metadata Fields

Cell line, Treatment

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accession-icon GSE49405
RMST associates with SOX2 to regulate neurogenesis
  • organism-icon Homo sapiens
  • sample-icon 1 Downloadable Sample
  • Technology Badge IconIllumina HumanHT-12 V4.0 expression beadchip, Illumina Genome Analyzer

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis.

Sample Metadata Fields

Cell line, Treatment

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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

fund-icon Fund the CCDL

Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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