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accession-icon SRP194395
Eimeria maxima-Induced Transcriptional Changes in the Cecal Mucosa of the Broiler Chickens
  • organism-icon Gallus gallus
  • sample-icon 6 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

Apicomplexan protozoans of Eimeria spp. cause coccidiosis, one of the most economically relevant parasitic diseases in chickens. The lack of a complete understanding of molecular mechanisms in host-parasite interaction limits the development of effective control measures. In the present study, RNA sequencing (RNA-seq) was applied to investigate the host mRNA profiles of the cecal mucosa and its contents collected at day 5 post Eimeria maxima (EM) infection.

Publication Title

No associated publication

Sample Metadata Fields

Sex, Specimen part, Cell line

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accession-icon SRP092744
Genes and polymorphism identification associated to hernias in swine
  • organism-icon Sus scrofa
  • sample-icon 8 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

Transcriptome of connective tissue of swine affected and non-affected with scrotal hernia

Publication Title

No associated publication

Sample Metadata Fields

Sex, Age, Specimen part, Disease

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accession-icon GSE109916
Compound PIP-RBPJ-1 treated human neural stem cells
  • organism-icon Homo sapiens
  • sample-icon 4 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 2.1 ST Array (hugene21st)

Description

The study of the compond PIP-RBPJ-1 function on neural stem cell. Synthetic DNA-binding inhibitors capable of gaining precise control over neurogenesis factors could obviate the current clinical barriers associated with small molecule use in regenerative medicine. Here, we show the design and bio-efficacy of a synthetic ligand PIP-RBPJ-1 to cause promoter-specific suppression of neurogenesis-associated HES1, and its downstream genes. Furthermore, PIP-RBPJ-1 alone could alter the neural system-associated notch signaling factors and remarkably induce neurogenesis with an efficiency that is comparable to a conventional approach. Here is one day treatment of the PIP-RBPJ-1 on neural stem cells.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon GSE25066
Genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer
  • organism-icon Homo sapiens
  • sample-icon 506 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer.

Sample Metadata Fields

Specimen part, Disease stage

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accession-icon GSE17705
Endocrine Sensitivity Index Validation Dataset
  • organism-icon Homo sapiens
  • sample-icon 298 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a)

Description

Validation dataset of 298 ER-positive patients treated with tamoxifen for 5 years.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part, Subject

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accession-icon GSE25055
Discovery cohort for genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer
  • organism-icon Homo sapiens
  • sample-icon 224 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a)

Description

PURPOSE: To develop a predictive test for response and survival following neoadjuvant taxane-anthracycline chemotherapy for HER2-negative invasive breast cancer.

Publication Title

A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer.

Sample Metadata Fields

Specimen part, Disease stage

View Samples
accession-icon GSE33116
Breast cancer and liver tissue biopsies used to develop and validate an index for liver contamination in metastatic breast cancer
  • organism-icon Homo sapiens
  • sample-icon 203 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a)

Description

PURPOSE: To develop an index capable of detecting and quantifying the extent of liver RNA contamination in liver biopsies of metastatic breast cancer

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon GSE25065
Validation cohort for genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer
  • organism-icon Homo sapiens
  • sample-icon 198 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a)

Description

PURPOSE: To develop a predictive test for response and survival following neoadjuvant taxane-anthracycline chemotherapy for HER2-negative invasive breast cancer.

Publication Title

A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer.

Sample Metadata Fields

Specimen part, Disease stage

View Samples
accession-icon GSE72220
Application of a clinical assay for staging and prognosis of prostate cancer diagnosed in needle core biopsy specimens
  • organism-icon Homo sapiens
  • sample-icon 147 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Exon 1.0 ST Array [transcript (gene) version (huex10st)

Description

Molecular and genomic analysis of microscopic quantities of tumor from formalin-fixed and paraffin-embedded (FFPE) biopsies has many unique challenges. Here we evaluated the feasibility of obtaining transcriptome-wide RNA expression to measure prognostic classifiers from diagnostic prostate needle core biopsies.

Publication Title

Application of a Clinical Whole-Transcriptome Assay for Staging and Prognosis of Prostate Cancer Diagnosed in Needle Core Biopsy Specimens.

Sample Metadata Fields

Specimen part, Subject

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accession-icon GSE72291
Validation of a genomic classifier for prediction of metastasis following postoperative radiation therapy.
  • organism-icon Homo sapiens
  • sample-icon 130 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Exon 1.0 ST Array [probe set (exon) version (huex10st)

Description

To test the hypothesis that a genomic classifier (GC) would predict biochemical failure (BF) and distant metastasis (DM) in men receiving radiation therapy (RT) after radical prostatectomy (RP).

Publication Title

The Landscape of Prognostic Outlier Genes in High-Risk Prostate Cancer.

Sample Metadata Fields

Age

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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

fund-icon Fund the CCDL

Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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