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accession-icon E-MTAB-2147
Transcription profiling by array of wild type, gis1 knockout, rph1 knockout, gis1rph1 double knockout, rph1-H235A mutant and gis1 knockout/rph1-H235A mutant yeast at different growth phases
  • organism-icon Saccharomyces cerevisiae
  • sample-icon 36 Downloadable Samples
  • Technology Badge Icon Affymetrix Yeast Genome 2.0 Array (yeast2)

Description

Gene regulatory significance of the JmjC domain H235A point mutation in the yeast transcription factor Rph1, in log and post-diauxic shift (pds) phase

Publication Title

The histone demethylase activity of Rph1 affects telomeric silencing but is not required for nutrient signaling

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE63068
Integrative genomic signatures of hepatocellular carcinoma derived from nonalcoholic fatty liver disease
  • organism-icon Mus musculus, Homo sapiens
  • sample-icon 67 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2), Affymetrix Mouse Genome 430 2.0 Array (mouse4302), Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Integrative genomic signatures of hepatocellular carcinoma derived from nonalcoholic Fatty liver disease.

Sample Metadata Fields

Age, Specimen part, Disease

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accession-icon GSE63027
Expression data from GNMT and MAT1A knockout models that develop all the stages of non-alcoholic fatty liver disease including hepatocellular carcinoma [GNMT_MAT1A_3&8_months]
  • organism-icon Mus musculus
  • sample-icon 35 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2), Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

Liver global gene expression patterns of 9 GNMT-knockout mice histopathologically determined to have non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) together with 10 MAT1A-knockout mice histopathologically determined to have steatosis and NASH. All these have their respective wild type patterns. These were analyzed to define signatures to study the pathogenesis of NAFLD-derived HCC, explore which subtypes of cancers can be investigated using mouse models and define a signature of HCC differential survival that can be used to characterize HCC subtypes of different survival derived from mixed etiologies.

Publication Title

Integrative genomic signatures of hepatocellular carcinoma derived from nonalcoholic Fatty liver disease.

Sample Metadata Fields

Age, Specimen part, Disease

View Samples
accession-icon E-MEXP-3630
Transcriptional profiling by array of pig brain tissues to study gene expression differences associated with abnormal tail biting behavior in pigs
  • organism-icon Sus scrofa
  • sample-icon 37 Downloadable Samples
  • Technology Badge Icon Affymetrix Porcine Genome Array (porcine)

Description

Gene expression in the hypothalamus and pre frontal cortex in pigs performing and receiving tail biting behaviour was compared with expression in pigs not performing or receiving tail biting

Publication Title

No associated publication

Sample Metadata Fields

Sex, Specimen part

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accession-icon GSE100083
Expression in equine cartilage stimulated with IL-1 in vitro
  • organism-icon Equus caballus
  • sample-icon 31 Downloadable Samples
  • Technology Badge Icon Equus caballus Gene 1.0 ST Array (equgene10st)

Description

The objective was to study the time-course effects of interleukin-1 (IL-1) on equine articular cartilage, with the aim to identify genes of relevance for cartilage pathology in osteoarthritis. Changes in gene expression related to inflammation, extracellular matrix, and phenotypic alterations was studied.

Publication Title

Time-dependent changes in gene expression induced in vitro by interleukin-1β in equine articular cartilage.

Sample Metadata Fields

Specimen part, Treatment

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accession-icon GSE75612
Gene expression in 0.5 mm root tips of Arabidopsis
  • organism-icon Arabidopsis thaliana
  • sample-icon 27 Downloadable Samples
  • Technology Badge Icon Affymetrix Arabidopsis ATH1 Genome Array (ath1121501)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

PHABULOSA Mediates an Auxin Signaling Loop to Regulate Vascular Patterning in Arabidopsis.

Sample Metadata Fields

Specimen part

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accession-icon GSE63067
Expression data from human non-alcoholic fatty liver disease stages
  • organism-icon Homo sapiens
  • sample-icon 17 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Global gene expression patterns of 2 human steatosis and 9 human non-alcoholic steatohepatitis (NASH) together with their respective control patterns were analyzed to define the non-alcoholic fatty liver disease (NAFLD) progression molecular characteristics and to define NASH early markers from steatosis.

Publication Title

Integrative genomic signatures of hepatocellular carcinoma derived from nonalcoholic Fatty liver disease.

Sample Metadata Fields

Specimen part, Disease

View Samples
accession-icon GSE63062
Expression data from GNMT and MAT1A knockout models that develop all the stages of non-alcoholic fatty liver disease including hepatocellular carcinoma [MAT1A_15months]
  • organism-icon Mus musculus
  • sample-icon 15 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2), Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Liver global gene expression patterns of 15-month-old MAT1A knockout mice histopathologically determined to have hepatocellular carcinoma (HCC). 5 samples are of tumoral tissue and 5 samples are of peritumoral tissue. All these have their respective wild type patterns. These were analyzed to define signatures to study the pathogenesis of NAFLD-derived HCC, explore which subtypes of cancers can be investigated using mouse models and define a signature of HCC differential survival that can be used to characterize HCC subtypes of different survival derived from mixed etiologies.

Publication Title

Integrative genomic signatures of hepatocellular carcinoma derived from nonalcoholic Fatty liver disease.

Sample Metadata Fields

Age, Specimen part, Disease

View Samples
accession-icon GSE62537
Expression data roots of Arabidopsis plants inoculated with Verticillium longisporum
  • organism-icon Arabidopsis thaliana
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Arabidopsis ATH1 Genome Array (ath1121501)

Description

Identification of genes differentially expressed in roots of Arabidopsis Col-0 and ndr1-1 mutants 48 h post inoculation with the fungal pathogen Verticillium longisporum.

Publication Title

Susceptibility to Verticillium longisporum is linked to monoterpene production by TPS23/27 in Arabidopsis.

Sample Metadata Fields

Age, Specimen part, Time

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accession-icon GSE75609
Gene expression in 0.5 mm root tips of Arabidopsis upon induction of pCRE1>>MIR165A
  • organism-icon Arabidopsis thaliana
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Arabidopsis ATH1 Genome Array (ath1121501)

Description

The class III HD-ZIPtranscription factors regulate vascular patterning in Arabidopsis thaliana roots. In this expression study we compare the expression profile in root tips upon miR165 induction, after 6h, 10h and 24h. The results are presented in PHABULOSA mediates an auxin signaling loop to regulate vascular patterning in Arabidopsis by Christina Joy Mller, Ana Elisa Valds, Guodong Wang, Prashanth Ramachandran, Lisa Beste, Daniel Uddenberg, and Annelie Carlsbecker, accepted for publication in Plant Physiology Nov. 2015.

Publication Title

PHABULOSA Mediates an Auxin Signaling Loop to Regulate Vascular Patterning in Arabidopsis.

Sample Metadata Fields

Specimen part

View Samples
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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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