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Mus musculus
62 Downloadable Samples
Affymetrix Murine Genome U74A Version 2 Array (mgu74av2), Affymetrix Murine Genome U74A Array (mgu74a), UNKNOWN, Affymetrix Murine 11K SubB Array (mu11ksubb), Affymetrix Murine 11K SubA Array (mu11ksuba)
Description
Mouse lymphoma L5178Y cells are treated with Mitomycin C [CAS:50-07-7;CHEBI:27504] and harvested at 4 and 24 hours for analysis.
Publication Title
The Utility of DNA Microarrays for Characterizing Genotoxicity
Sample Metadata Fields
Sex, Disease, Disease stage, Compound, Time
View Samples- Mus musculus
- 58 Downloadable Samples
- Affymetrix Murine Genome U74A Version 2 Array (mgu74av2), Affymetrix Murine Genome U74A Array (mgu74a), UNKNOWN
Description
Mouse lymphoma L5178Y cells are treated with Taxol (Paclitaxel) [CAS:33069-62-4;CHEBI:7887] and harvested at 4 and 24 hours for analysis.
Publication Title
Toxicogenomics in Risk Assessment: An Overview of an HESI Collaborative Research Program
Sample Metadata Fields
Sex, Disease, Disease stage, Compound, Time
View Samples- Mus musculus, Homo sapiens
- 59 Downloadable Samples
- Affymetrix Murine Genome U74A Version 2 Array (mgu74av2), Affymetrix Murine Genome U74A Array (mgu74a), Affymetrix Human Genome U95A Array (hgu95a)
Description
Mouse lymphoma L5178Y and Human TK6 cells are treated with Methylmethane Sulfonate [CAS:66-27-3;CHEBI:25255] and harvested a 4 and 24 hours for analysis.
Publication Title
The Utility of DNA Microarrays for Characterizing Genotoxicity
Sample Metadata Fields
Sex, Disease, Disease stage, Compound, Time
View Samples- Mus musculus
- 12 Downloadable Samples
- Affymetrix Murine Genome U74A Version 2 Array (mgu74av2)
Description
Mouse lymphoma L5178Y cells are treated with Etoposide [CAS:33419-42-0;CHEBI:4911] and harvested a 4 and 24 hours for analysis.
Publication Title
Toxicogenomics in Risk Assessment: An Overview of an HESI Collaborative Research Program
Sample Metadata Fields
Sex, Disease, Disease stage, Compound, Time
View Samples- Mus musculus
- 2 Downloadable Samples
- UNKNOWN
Description
Mouse lymphoma L5178Y cells are treated with 4-NitroQuinoline N-Oxide (4-NQO) [CAS:56-57-5;CHEBI:16907] and harvested at 4 and 24 hours for analysis.
Publication Title
The Utility of DNA Microarrays for Characterizing Genotoxicity
Sample Metadata Fields
Sex, Disease, Disease stage, Compound, Time
View Samples- Rattus norvegicus
- 134 Downloadable Samples
- UNKNOWN
Description
BACKGROUND: The use of gene expression profiling in both clinical and laboratory settings would be enhanced by better characterization of variance due to individual, environmental, and technical factors. Meta-analysis of microarray data from untreated or vehicle-treated animals within the control arm of toxicogenomics studies could yield useful information on baseline fluctuations in gene expression, although control animal data has not been available on a scale and in a form best served for data-mining. RESULTS: A dataset of control animal microarray expression data was assembled by a working group of the Health and Environmental Sciences Institute's Technical Committee on the Application of Genomics in Mechanism Based Risk Assessment in order to provide a public resource for assessments of variability in baseline gene expression. Data from over 500 Affymetrix microarrays from control rat liver and kidney were collected from 16 different institutions. Thirty-five biological and technical factors were obtained for each animal, describing a wide range of study characteristics, and a subset were evaluated in detail for their contribution to total variability using multivariate statistical and graphical techniques. CONCLUSIONS: The study factors that emerged as key sources of variability included gender, organ section, strain, and fasting state. These and other study factors were identified as key descriptors that should be included in the minimal information about a toxicogenomics study needed for interpretation of results by an independent source. Genes that are the most and least variable, gender-selective, or altered by fasting were also identified and functionally categorized. Better characterization of gene expression variability in control animals will aid in the design of toxicogenomics studies and in the interpretation of their results. [based on information contained in Final_HESI_Decoder_483_05_015_07.txt provided by CEBS database]
Publication Title
Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories
Sample Metadata Fields
Sex, Specimen part
View Samples- Rattus norvegicus
- 90 Downloadable Samples
- Affymetrix Rat Genome 230 2.0 Array (rat2302)
Description
Microcystins are produced by the cyanobacteria, most commonly Microcystis aerginosa. Upon ingestion, toxic microcystins are actively absorbed by fish, birds and mammals where they are primarily liver toxins.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part, Compound, Time
View Samples
GSE137433- Mus musculus
- 12 Downloadable Samples
- Affymetrix Mouse Genome 430 2.0 Array (mouse4302)
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms.
Sample Metadata Fields
Specimen part, Disease, Disease stage, Treatment
View Samples- Homo sapiens
- 12 Downloadable Samples
- Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
An Ancient Fecundability-Associated Polymorphism Creates a GATA2 Binding Site in a Distal Enhancer of HLA-F.
Sample Metadata Fields
Sex, Specimen part
View Samples- Mus musculus
- 12 Downloadable Samples
- Affymetrix Mouse Genome 430 2.0 Array (mouse4302)
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function.
Sample Metadata Fields
Sex, Age, Specimen part, Treatment
View Samples