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accession-icon SRP034706
Urechis unicinctus Transcriptome or Gene expression
  • organism-icon Mus musculus
  • sample-icon 1 Downloadable Sample
  • Technology Badge IconIllumina HiSeq 2000

Description

Urechis unicinctus, a benthic marine worm inhabiting widely in the coast of Russia, Japan, Korean Peninsula and China, presents special biological characteristics in morphology, reproductive and developmental biology as well as physiology. It could exist in condition of low oxygen, high sulfide and pollution where most animals could not live.However, the molecular mechanisms of resistance are still unknown and the main obstacle to further study is the limited genomic and genetic information.

Publication Title

No associated publication

Sample Metadata Fields

No sample metadata fields

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accession-icon SRP034687
Urechis unicinctus strain:echiuran worm Transcriptome or Gene expression
  • organism-icon Mus musculus
  • sample-icon 1 Downloadable Sample
  • Technology Badge IconIllumina HiSeq 2000

Description

Urechis unicinctus, a benthic marine worm inhabiting widely in the coast of Russia, Japan, Korean Peninsula and China, present special biological characteristics in morphology, reproductive and developmental biology as well as physiology. It could exist in condition of low oxygen, high sulfide and pollution where most animals could not live. However, the molecular mechanisms of resistance are still unknown and the main obstacle to further study is the limited genomic and genetic information. In order to improve the situation, we performed and acquired its transcriptome database.

Publication Title

No associated publication

Sample Metadata Fields

No sample metadata fields

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accession-icon SRP066758
Populus trichocarpa root raw sequence reads
  • organism-icon Populus trichocarpa
  • sample-icon 3 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2000

Description

The goal of this study is to investigate the genes regulated by histone acetylation during root development.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon SRP132125
ZmGRP1 CRISPR/Cas9 RNA sequencing
  • organism-icon Zea mays
  • sample-icon 7 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

To study the splicing factor role of ZmGRP1

Publication Title

No associated publication

Sample Metadata Fields

Sex, Specimen part, Disease, Disease stage, Cell line, Treatment

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accession-icon GSE34193
Microarray data Ptf1a gain-of-function Xenopus pancreas development
  • organism-icon Xenopus laevis
  • sample-icon 14 Downloadable Samples
  • Technology Badge Icon Affymetrix Xenopus laevis Genome 2.0 Array (xlaevis2)

Description

The Ptf1a gene has essential functions during several stages of pancreas development. It is expressed in the nave endoderm and required pancreas cell fate specification; it is also required later in the differentiation and maintenance of acinar cells. To identify the regulatory genetic program downstream of Ptf1a required for early pancreatic fate acquisition, we used microarrays to perform a comprehensive gene expression analysis of Ptf1a overexpressing endodermal tissue at NF32 and NF36.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon GSE29017
Expression data from Xenopus endoderm at stage 15 following four hours of Ngn3-GR overexpression
  • organism-icon Xenopus laevis
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Xenopus laevis Genome 2.0 Array (xlaevis2)

Description

Ngn3 is a master regulator of pancreatic endocrine development. It is necessary for the creation of all endocrine cells in mice. Little is known about the genes that act downstream of the transcription factor Ngn3 in pancreas endocrine development to specify each of the endocrine lineages. As a consequence, little is known about the genes involved in early development and the specification of the beta cell. We used microarrays to identify Ngn3 downstream genes that are involved in early and ectopic beta cell development in Xenopus laevis. We overexpressed Ngn3 in the Xenopus early endoderm and analyzed the genes that are upregulated four hours after.

Publication Title

Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells.

Sample Metadata Fields

Specimen part, Treatment

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accession-icon SRP065059
Zea mays cultivar:Shandan 609 Raw sequence reads
  • organism-icon Zea mays
  • sample-icon 4 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2000

Description

This study provide a dynamic atlas of endosperm development from Shaanxi within China

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon SRP096846
Histone Acetyltransferase GCN5 Contributes to Stem Cuticular Wax Biosynthesis by Acetylating ECERIFERUM 3 (CER3) in Arabidopsis thaliana
  • organism-icon Arabidopsis thaliana
  • sample-icon 6 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

Cuticular wax is a major composition of plant surface cuticle, which exerts crucial functions in optimizing plant growth. Histone acetylation regulates gene expression of diverse biological processes, but little is known about its role in cuticular wax synthesis. Here we observed that mutation of Arabidopsis histone acetyltransferase GCN5 gene impaired stem cuticular wax accumulation. Furthermore, three target genes of GCN5 (CER3, CER26 and CER1-L1) were identified by RNA-Seq and ChIP assays. Consistently, H3K9/14 acetylation levels in promoter regions of CER3, CER26 and CER1-L1 were significantly decreased in gcn5 as compared to wild type. Notably, overexpression of CER3 in the gcn5 mutant restored the stem cuticular wax accumulation. Collectively, these data demonstrate that Arabidopsis GCN5 is involved in stem cuticular wax accumulation by modulating CER3 expression via H3K9/14 acetylation, which present evidence that histone acetylation plays an important role in cuticular wax biosynthesis

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon GSE55570
Gene expression data of two different strains of laying hens from a small group housing system
  • organism-icon Gallus gallus
  • sample-icon 60 Downloadable Samples
  • Technology Badge Icon Affymetrix Chicken Gene 1.0 ST Array (chigene10st)

Description

We used a chicken RNA microarray to identify differentially expressed genes in order to compare two layer lines kept in a small group housing system Eurovent Deutsch.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon SRP015012
Gallus gallus Oviduct Transcriptome
  • organism-icon Gallus gallus
  • sample-icon 6 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2000

Description

Using HiSeq2000 to sequence white leghorn different parts (ovary, magnum, isthmus and uterus) of oviduct at 40-weeks.

Publication Title

No associated publication

Sample Metadata Fields

No sample metadata fields

View Samples
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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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