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accession-icon SRP066758
Populus trichocarpa root raw sequence reads
  • organism-icon Populus trichocarpa
  • sample-icon 3 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2000

Description

The goal of this study is to investigate the genes regulated by histone acetylation during root development.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon SRP034687
Urechis unicinctus strain:echiuran worm Transcriptome or Gene expression
  • organism-icon Mus musculus
  • sample-icon 1 Downloadable Sample
  • Technology Badge IconIllumina HiSeq 2000

Description

Urechis unicinctus, a benthic marine worm inhabiting widely in the coast of Russia, Japan, Korean Peninsula and China, present special biological characteristics in morphology, reproductive and developmental biology as well as physiology. It could exist in condition of low oxygen, high sulfide and pollution where most animals could not live. However, the molecular mechanisms of resistance are still unknown and the main obstacle to further study is the limited genomic and genetic information. In order to improve the situation, we performed and acquired its transcriptome database.

Publication Title

No associated publication

Sample Metadata Fields

No sample metadata fields

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accession-icon SRP034706
Urechis unicinctus Transcriptome or Gene expression
  • organism-icon Mus musculus
  • sample-icon 1 Downloadable Sample
  • Technology Badge IconIllumina HiSeq 2000

Description

Urechis unicinctus, a benthic marine worm inhabiting widely in the coast of Russia, Japan, Korean Peninsula and China, presents special biological characteristics in morphology, reproductive and developmental biology as well as physiology. It could exist in condition of low oxygen, high sulfide and pollution where most animals could not live.However, the molecular mechanisms of resistance are still unknown and the main obstacle to further study is the limited genomic and genetic information.

Publication Title

No associated publication

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon SRP132125
ZmGRP1 CRISPR/Cas9 RNA sequencing
  • organism-icon Zea mays
  • sample-icon 7 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

To study the splicing factor role of ZmGRP1

Publication Title

No associated publication

Sample Metadata Fields

Sex, Specimen part, Disease, Disease stage, Cell line, Treatment

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accession-icon SRP169067
maize nucellus sequencing
  • organism-icon Zea mays
  • sample-icon 56 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 1500

Description

Transcriptome dynamics of nucellus in early maize seed

Publication Title

High Temporal-Resolution Transcriptome Landscape of Early Maize Seed Development.

Sample Metadata Fields

Age, Specimen part

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accession-icon SRP009841
RNA seq-based liver transcriptome analysis revealed an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish
  • organism-icon Danio rerio
  • sample-icon 6 Downloadable Samples
  • Technology Badge IconIlluminaHiSeq2000

Description

The zebrafish (Danio rerio) is a prominent vertebrate development model, has been extensively utilized as the pathogen-host interaction to be studied in recent years. However, the mechanisms involved in the immune response of the zebrafish to vaccine are not fully understood. For clarify the high immune relative protection in zebrafish following the immunization of the putative Edwardsiella tarda (E. tarda) live attenuate vaccine, we performed a comparative gene expression analysis of mocked and immunized zebrafish using the RNA-seq technology and DEGseq to identify differential expressed genes, chiefly for gaining deep insight into the liver immunogenetics after WEDplas vaccinated zebrafish.

Publication Title

No associated publication

Sample Metadata Fields

No sample metadata fields

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accession-icon SRP142026
Saccharomyces cerevisiae Raw sequence reads
  • organism-icon Saccharomyces cerevisiae
  • sample-icon 34 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

As an ancient winning strategy of microorganisms, glucose repression mechanism has become specialized to perfection in Saccharomyces cerevisiae. The galactose (GAL) metabolism network is stringently regulated by glucose repression in yeast and has been a classic system for studying gene regulation. We show here that the population of S. cerevisiae living in fermented milks has autonomously reinstated an ancient version of the structural GAL genes through introgression. The introgressed GAL network has completely abolished the glucose repression and conversed from a strictly inducible to a constitutive system through coordinative polygenic changes in the regulatory components of the network, including transitions in the upstream repressing sequence site of GAL4 that impair Mig1p-mediated repression and loss of function of the inducer Gal3p and the repressor Gal80p. In addition, the introgressed GAL2 gene has been duplicated while the native HXT6 and HXT7 genes have been inactivated, resulting in galactose-over-glucose preference and elevated galactose utilization rate. Relying on the reverse evolution of the GAL network, the non-lactose fermenting yeast has become a dominant species co-existing with other lactose fermenting microorganisms in fermented milks. Our results also provide new clues for developing yeast strains devoid of barriers to co-utilization of different sugars.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part, Disease, Cell line

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accession-icon SRP151834
RNA-seq results of WT and CKIP-1 KO mouse macrophages
  • organism-icon Mus musculus
  • sample-icon 2 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2000

Description

The differential expression of gene in bone marrow derived macrophages from Ckip-1 KO mice and WT mice.

Publication Title

No associated publication

Sample Metadata Fields

Sex, Age, Specimen part, Cell line

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accession-icon SRP065059
Zea mays cultivar:Shandan 609 Raw sequence reads
  • organism-icon Zea mays
  • sample-icon 4 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2000

Description

This study provide a dynamic atlas of endosperm development from Shaanxi within China

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon SRP096846
Histone Acetyltransferase GCN5 Contributes to Stem Cuticular Wax Biosynthesis by Acetylating ECERIFERUM 3 (CER3) in Arabidopsis thaliana
  • organism-icon Arabidopsis thaliana
  • sample-icon 6 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

Cuticular wax is a major composition of plant surface cuticle, which exerts crucial functions in optimizing plant growth. Histone acetylation regulates gene expression of diverse biological processes, but little is known about its role in cuticular wax synthesis. Here we observed that mutation of Arabidopsis histone acetyltransferase GCN5 gene impaired stem cuticular wax accumulation. Furthermore, three target genes of GCN5 (CER3, CER26 and CER1-L1) were identified by RNA-Seq and ChIP assays. Consistently, H3K9/14 acetylation levels in promoter regions of CER3, CER26 and CER1-L1 were significantly decreased in gcn5 as compared to wild type. Notably, overexpression of CER3 in the gcn5 mutant restored the stem cuticular wax accumulation. Collectively, these data demonstrate that Arabidopsis GCN5 is involved in stem cuticular wax accumulation by modulating CER3 expression via H3K9/14 acetylation, which present evidence that histone acetylation plays an important role in cuticular wax biosynthesis

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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