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accession-icon SRP072829
Transcriptome analysis of CNS leukemia
  • organism-icon Homo sapiens
  • sample-icon 15 Downloadable Samples
  • Technology Badge IconNextSeq 500

Description

The goal of this study is to reveal the characters and therapeutic targets of CNS leukemia.

Publication Title

No associated publication

Sample Metadata Fields

Sex, Age, Specimen part, Disease

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accession-icon SRP045672
RNA-seq transcriptome analysis of mouse cell lines
  • organism-icon Mus musculus
  • sample-icon 7 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2000

Description

Building the gene expression profiles and identifying the differentially expressed genes in specific comparisons.

Publication Title

No associated publication

Sample Metadata Fields

No sample metadata fields

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accession-icon SRP044280
Mus musculus Transcriptome or Gene expression
  • organism-icon Mus musculus
  • sample-icon 2 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

RNA-seq of single embryo

Publication Title

No associated publication

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE19820
Expression data from rat pluripotent stem (PS) cells
  • organism-icon Rattus norvegicus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Rat Genome 230 2.0 Array (rat2302)

Description

Various pluripotent stem (PS) cells can be isolated from early developing embryos in mouse. Among these, two kinds of PS cells were isolated from mouse blastocysts: conventional embryonic stem (ES) cells with domed morphology that are maintained with LIF and BMP for self-renewal, and FAB-ES cells with flat morphology that need bFGF, activinA and BIO for self-renewal. Here, we report a novel PS cell line from rat blastocysts, which is distinguishable from conventional ES cells but is morphologically similar to mouse epiblast stem cell (EpiSC) lines. We used microarrays to detail the global program of gene expression of rES and rPS.

Publication Title

The heterogeneity and dynamic equilibrium of rat embryonic stem cells.

Sample Metadata Fields

Specimen part

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accession-icon GSE2192
Differentiation of NIH-3T3 cells to adipocytes by PPARg or EBF1 over-expression.
  • organism-icon Mus musculus
  • sample-icon 53 Downloadable Samples
  • Technology Badge Icon Affymetrix Murine Genome U74A Version 2 Array (mgu74av2)

Description

NIH-3T3 cells transduced with either EBF1-, PPARg2- or empty vector were stimulated with hormones to initiate adipocyte differentiation. RNA extraction was done using TriZol at d0, d2, d4 and d10 after stimulation. Samples were handled according to standard affymetrix protocols.

Publication Title

Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics.

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE34551
NPTX1 is a Critical Regulator of Neural Induction in Human Pluripotent Stem Cells
  • organism-icon Homo sapiens
  • sample-icon 29 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 1.0 ST Array (hugene10st)

Description

NPTX1 is a key inducer of neural lineages from the human ESC.

Publication Title

NPTX1 regulates neural lineage specification from human pluripotent stem cells.

Sample Metadata Fields

Cell line, Time

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accession-icon GSE55129
The role of Rif1 in ES cells
  • organism-icon Mus musculus
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

Purpose:The goals of this study are to understand the mechanisms underlying reduced self-renewal and loss of pluripotency by depletion of Rif1.

Publication Title

Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing.

Sample Metadata Fields

Cell line

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accession-icon GSE76923
Expression data for hiPSC-derived RPE treated with 10mM Nicotinamide or vehicle
  • organism-icon Homo sapiens
  • sample-icon 3 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 2.0 ST Array (hugene20st)

Description

Nicotinamide (NAM) inhibited the expression of Age related macular degeneration (AMD) associated proteins in hiPSC-derived retinal pigment epithelium (RPE).

Publication Title

No associated publication

Sample Metadata Fields

Disease, Treatment

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accession-icon SRP127783
Homo sapiens Transcriptome or Gene expression
  • organism-icon Homo sapiens
  • sample-icon 5 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

RNA-Seq analysis was performed to identify differentially expressed transcripts in primary AML bone marrow derived mononuclear cells compared to healthy (normal) peripheral blood mononuclear cells.

Publication Title

No associated publication

Sample Metadata Fields

Sex, Age, Specimen part, Disease, Disease stage, Race

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accession-icon SRP127642
Transcriptome Analysis of wild type and SMARCB1 knock down HL60 leukemia cell line by Next Generation Sequencing
  • organism-icon Homo sapiens
  • sample-icon 4 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 4000

Description

We have used lentiviral mediated knock down of SMARCB1, a subunit of the mammalian SWI/SNF complex in HL60, an acute promyelocytic leukemia cell line followed by high throughput mRNA sequencing to identify differentially expressed genes. We have used this data to identify genes affected by SMARCB1 depletion, and thus understand contribution of SMARCB1 towards leukemogenesis.

Publication Title

No associated publication

Sample Metadata Fields

Sex, Age, Specimen part, Cell line

View Samples
...

refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

fund-icon Fund the CCDL

Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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